Evolution of Osmosensory MAP Kinase Signaling Pathways
نویسندگان
چکیده
منابع مشابه
Evolution of Osmosensory MAP Kinase Signaling Pathways1
SYNOPSIS. Mitogen-activated protein (MAP) kinases constitute a large family of proteins with many functions. They are represented by a multitude of paralogous isoforms in yeast, vertebrates, and other eukaryotes. A phylogenetically conserved function of MAP kinases is to carry osmotic signals from sensory to target elements of cells. Even though this function of MAP kinases is ubiquitous and ch...
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Mitogen-activated protein (Map) kinases are widely expressed serine-threonine kinases that mediate important regulatory signals in the cell. Three major groups of Map kinases exist: the p38 Map kinase family, the extracellular signal-regulated kinase (Erk) family, and the c-Jun NH2-terminal kinase (JNK) family. The members of the different Map kinase groups participate in the generation of vari...
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Mitogen-activated protein kinase (MAPK) pathways regulate diverse processes ranging from proliferation and differentiation to apoptosis. Activated by an enormous array of stimuli, they phosphorylate numerous proteins, including transcription factors, cytoskeletal proteins, kinases and other enzymes, and greatly influence gene expression, metabolism, cell division, cell morphology and cell survi...
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Mitogen-activated protein kinase (MAPK) modules containing three sequentially activated protein kinases are key components of a series of vital signal transduction pathways that regulate processes such as cell proliferation, cell differentiation, and cell death in eukaryotes from yeast to humans (Fig. 1) (Qi and Elion 2005; Raman et al. 2007; Keshet and Seger 2010). Each cascade is initiated by...
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Cells respond to changes in osmotic pressure with compensatory molecular adaptations that allow them to re-establish homeostasis of osmotically disturbed aspects of cell structure and function. In addition, some cell types respond to osmotic stress by changing their phenotype or, if their tolerance threshold is exceeded, by initiating programmed cell death. To understand how cells achieve these...
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ژورنال
عنوان ژورنال: American Zoologist
سال: 2001
ISSN: 0003-1569
DOI: 10.1093/icb/41.4.743